African Men At Higher Risk of Prostrate Cancer – Research Says

A number of recently conducted research is now linking African ancestry to an heightened risk of prostate cancer and the possibility of more aggressive disease progression. A landmark study by the Men of African Descent and Carcinoma of the Prostate Consortium (MADCaP) Published in the journal Nature Genetics in October, which analysed data from nearly 8,000 participants across five African countries, is shedding light on the genetic risks specific to African men. The research, which is the largest genome study on prostate cancer conducted on the continent revealed three genetic regions, or loci, associated with higher prostate cancer risk, with variations unique to African populations.

According to the researchers these findings highlight the importance of modifying screening and treatment strategies to reflect the genetic diversity of African populations.

A lead researcher with MADCaP named Carl Chen said that the study’s focus on African genomes allowed researchers to uncover genetic markers that have often been overlooked in studies focusing on non-African populations.

“By focusing on African populations, we uncovered critical genetic risk factors previously unidentified,” he said.

“This approach highlights Africa’s unique genetic landscape and lays a foundation for interventions that could address the specific health needs of African men.”

“With data specific to African genetics, we’re in a better position to inform screening protocols that could improve survival rates,” he added.

In many African countries, misinformation and stigma around prostate cancer screening prevent men from seeking timely testing. For instance, in Nigeria a lot of men misguidedly believe that screening involves invasive procedures, which discourages participation.

To address these challenges early intervention is vital for managing prostate cancer, Chen explained.

Beyond raising awareness, Chen and his co-authors say local investment in prostate cancer research is crucial for improving outcomes.

“Establishing research facilities and training scientists in Africa is essential to addressing the continent’s health challenges,” Chen said.

“This study demonstrates that African researchers can and should lead research on health issues affecting African populations.”

While infectious diseases such as HIV and tuberculosis have traditionally dominated Africa’s health agenda, Chen and his colleagues argue that non-communicable diseases like prostate cancer require dedicated attention and resources.

With prostate cancer among the leading causes of cancer-related deaths in African men, Dare-Johnson opines that locally informed strategies offer an opportunity to significantly improve survival rates.