Too Much Salt Causes Cognitive Impairment
A new research shows how a high-salt diet could result to excessive levels of interleukin-17 (IL-17) in multiple sclerosis (MS) patients, causing changes in endothelial cells that result in dementia.
These findings suggest that therapeutics targeting IL-17 may help halt the neurovascular damages of MS and other autoimmune diseases linked to high levels of IL-17.
Diets rich in sodium chloride are common among Americans, 90 percent of whom surpass the recommended 2,300 mg intake of salt per day. While such diets have been connected with an increased risk for cerebrovascular diseases and dementia, exactly how high levels of salt harm the brain remained unclear.
Eager to find out, researchers at New York’s Weill Cornell University fed mice a high-salt diet, either with 4 or 8 percent of salt, corresponding to a 8- to 16-fold increase in salt content compared to a regular mouse diet.

